A prospective study of hepatitis C virus infection after needlestick accidents.
There have been few prospective studies of hepatitis C virus (HCV) infection after needlestick accidents in hospital employees.
In the present study, the prevalence and features of HCV infection after needlestick accidents were evaluated prospectively measuring serum HCV-RNA.
Subjects were 56 employees who had HCV needlestick accidents.
To monitor the development of hepatitis, the serum ALT levels and HCV-related seromarkers, such as first generation anti-HCV (RIA), second generation anti-HCV (PHA) and HCV-RNA (RT-PCR) were measured every month for at least 12 months after the accidents.
Three of 56 (5.4%) recipients developed HCV infection.
HCV-RNA was detected in all three recipients within 4 months after the exposure, and second-generation HCV antibody was detected in two of three recipients.
The detection of HCV-RNA was earlier than that of HCV antibody.
Two of three HCV-infected recipients developed type C acute hepatitis and one of two received interferon therapy ; however, the other case received no medication.
The detection of HCV-related seromarkers and the elevation of ALT levels were transient in these three recipients ; thus, none developed chronic hepatitis.
In conclusion, HCV infection developed in 5.4% of recipients within 4 months after HCV accidents.
All of these HCV-infected recipients showed fair prognosis.
HCV-RNA was a beneficial parameter for early detection of HCV infection.
Mots-clés Pascal : Exposition professionnelle, Piqûre, Aiguille, Hépatite virale C, Virose, Infection, Complication, Diagnostic, Exploration microbiologique, RNA, Virus hépatite C, Flaviviridae, Virus, Réaction chaîne polymérase, Etude statistique, Homme, Médecine travail, Appareil digestif pathologie, Foie pathologie, Biologie moléculaire
Mots-clés Pascal anglais : Occupational exposure, Sting, Needle, Viral hepatitis C, Viral disease, Infection, Complication, Diagnosis, Microbiological investigation, RNA, Hepatitis C virus, Flaviviridae, Virus, Polymerase chain reaction, Statistical study, Human, Occupational medicine, Digestive diseases, Hepatic disease, Molecular biology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0022669
Code Inist : 002B05C02G. Création : 21/05/1997.