This long-term prospective study of patients with newly diagnosed RA assesses the relative value of certain clinical and laboratory measures at first consultation in order to determine factors that help to discriminate between patients likely to go into early remission and those with relapsing/remitting or persistent disease.
Validation was sought in a similar group from a separate but comparable prospective study.
Measures of clinical activity such as joint score, early morning stiffness (EMS) and acute phase (ESR) improved over 4 yr in both groups, whereas agalactosyl IgG [Gal (o) ] levels increased.
Using discriminant functional analysis in the first cohort to identify features at entry which would predict outcome at 4 yr, a combination of Gal (o), grip strength, age at onset and gender predicted the course of RA correctly in 95% of the patients.
This combination was confirmed in the second cohort, although with reduced power (78% correct).
Thus, we show that Gal (o) does not reflect activity of the disease like the ESR, but has greater potential as a prognostic index early in the course of disease.
Mots-clés Pascal : Polyarthrite rhumatoïde, Homme, Facteur risque, Pronostic, IgG, Immunoglobuline, Galactose, Glycosylation, Epidémiologie, Evolutivité, Dosage, Marqueur biologique, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Immunopathologie, Maladie autoimmune
Mots-clés Pascal anglais : Rheumatoid arthritis, Human, Risk factor, Prognosis, IgG, Immunoglobulins, Galactose, Glycosylation, Epidemiology, Evolutivity, Assay, Biological marker, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Immunopathology, Autoimmune disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0017361
Code Inist : 002B15D. Création : 21/05/1997.