Management of Clostridium difficile infection and other antibiotic-associated diarrhoeas.

Management of Clostridium difficile infection and other antibiotic-associated diarrhoeas.

Réf. 136150 Article - En anglais

EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol. 8, n° 11, 1996, pages 1054-1061, 86 réf., ISSN 0954-691X, GBR

BARTLETT (J.G.) ^*

Most cases of antibiotic-associated diarrhoea are due to Clostridium difficile or are enigmatic.
Patients with C.
Difficile-associated disease are more likely to have colitis, severe disease and nosocomial acquisition.
The preferred diagnostic test is a C. difficile toxin assay using a tissue culture assay or enzyme immunoassay.
The usual treatment is withdrawal of the inducing agent, sometimes supplemented with oral vancomycin or metronidazole.
Response rates approach 100% ; the major complication is relapse.
Major complications include toxic megacolon, devastating diarrhoea, pseudomembranous colitis and hypoalbuminemia.
Antibiotic-associated diarrhoea with negative tests for C. difficile toxin is usually dose-related and responds to antibiotic withdrawal.

Mots-clés BDSP : Diarrhée, Bactériose, Infection, Bactérie, Thérapeutique médicamenteuse, Médicament antibiotique, Diagnostic, Stratégie, Thérapeutique, Résultat, Homme, Appareil digestif [pathologie], Intestin [pathologie], Pharmacovigilance, Toxicologie

Mots-clés Pascal : Diarrhée, Bactériose, Infection, Clostridium difficile, Clostridiaceae, Clostridiales, Bactérie, Infection nosocomiale, Toxicité, Chimiothérapie, Antibiotique, Diagnostic, Stratégie, Traitement, Résultat, Homme, Appareil digestif pathologie, Intestin pathologie, Pharmacovigilance, Toxicologie

Mots-clés Pascal anglais : Diarrhea, Bacteriosis, Infection, Clostridium difficile, Clostridiaceae, Clostridiales, Bacteria, Nosocomial infection, Toxicity, Chemotherapy, Antibiotic, Diagnosis, Strategy, Treatment, Result, Human, Digestive diseases, Intestinal disease, Pharmacovigilance, Toxicology

Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique

Cote : 97-0016831
Code Inist : 002B02H. Création : 21/05/1997.

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