The aim of this study was to assess the correlation and average cost of total lymphocyte count compared with CD4 count as a broad estimate of immunosuppression in HIV-1 infected individuals.
Spearman's partial rank correlation were calculated between total lymphocyte count, absolute CD4 count and CD4 per cent stratified by stage of HIV-1 infection for routinely collected samples.
Data were collected prospectively from a T cell-subset register combined with clinical data obtained retrospectively from case notes of HIV-infected patients managed at St Mary's Hospital, London 1982-1991.
Costing data were obtained through a survey of the departments of haematology and immunology (1989/90 prices).
The correlation between 1534 paired absolute lymphocyte count and CD4 lymphocyte count was found to be high (R=0.76).
When analysed by stage of HIV infection, the correlation increased from R=0.64 for asymptomatic patients, to R=0.72 for patients with symptomatic non-AIDS HIV infection and R=0.73 for AIDS patients.
Correlations between absolute lymphocyte count and CD4 per cent were considerably weaker :
R=0.41 all paired counts ;
R=0.32 for asymptomatic patients ;
R=0.25 for symptomatic non-AIDS patients ;
R=0.32 for AIDS patients.
Average cost was £8 per full blood count compared with £38 per T-cell subset analysis. (...)
Mots-clés Pascal : SIDA, Virose, Infection, Numération, Analyse quantitative, Sous population cellulaire, Coût, Surveillance, Lymphocyte T, Stade clinique, Marqueur biologique, Homme, Immunodéficit, Immunopathologie, Economie santé, Antigène CD4
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Numeration, Quantitative analysis, Cell subpopulation, Costs, Surveillance, T-Lymphocyte, Clinical stage, Biological marker, Human, Immune deficiency, Immunopathology, Health economy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0015797
Code Inist : 002B06D01. Création : 21/05/1997.