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  1. Correlation between total and CD4 lymphocyte counts in HIV infection : not making the good an enemy of the not so perfect.

    Article - En anglais

    The aim of this study was to assess the correlation and average cost of total lymphocyte count compared with CD4 count as a broad estimate of immunosuppression in HIV-1 infected individuals.

    Spearman's partial rank correlation were calculated between total lymphocyte count, absolute CD4 count and CD4 per cent stratified by stage of HIV-1 infection for routinely collected samples.

    Data were collected prospectively from a T cell-subset register combined with clinical data obtained retrospectively from case notes of HIV-infected patients managed at St Mary's Hospital, London 1982-1991.

    Costing data were obtained through a survey of the departments of haematology and immunology (1989/90 prices).

    The correlation between 1534 paired absolute lymphocyte count and CD4 lymphocyte count was found to be high (R=0.76).

    When analysed by stage of HIV infection, the correlation increased from R=0.64 for asymptomatic patients, to R=0.72 for patients with symptomatic non-AIDS HIV infection and R=0.73 for AIDS patients.

    Correlations between absolute lymphocyte count and CD4 per cent were considerably weaker :

    • R=0.41 all paired counts ;

    • R=0.32 for asymptomatic patients ;

    • R=0.25 for symptomatic non-AIDS patients ;

    • R=0.32 for AIDS patients.

    Average cost was £8 per full blood count compared with £38 per T-cell subset analysis. (...)

    Mots-clés Pascal : SIDA, Virose, Infection, Numération, Analyse quantitative, Sous population cellulaire, Coût, Surveillance, Lymphocyte T, Stade clinique, Marqueur biologique, Homme, Immunodéficit, Immunopathologie, Economie santé, Antigène CD4

    Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Numeration, Quantitative analysis, Cell subpopulation, Costs, Surveillance, T-Lymphocyte, Clinical stage, Biological marker, Human, Immune deficiency, Immunopathology, Health economy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0015797

    Code Inist : 002B06D01. Création : 21/05/1997.