Race and sex differences in the distribution of cerebral atherosclerosis.
Background and Purpose The purpose of this study was to assess the influence of race, sex, and other risk factors on the location of atherosclerotic occlusive lesions in cerebral vessels.
Previous angiographic studies of patients with stroke or transient ischemic attack (TIA) suggest that extracranial atherosclerosis is more common in whites and intracranial disease is more common in blacks.
Noninvasive techniques such as duplex ultrasound, transcranial Doppler (TCD), and magnetic resonance angiography (MRA) allow vascular assessment of a more representative proportion of patients than does conventional angiography alone.
Methods Consecutive patients evaluated at a community hospital for stroke or TIA over a 2-year period were reviewed.
Lesions were defined as a 50% or greater atherosclerotic stenosis by angiography, duplex ultrasound, or TCD, or a moderate stenosis by MRA.
Results Whites were more likely than blacks to have extracranial carotid artery lesions (33% versus 15%, P=001), but the proportion of patients with intracranial lesions was similar (24% versus 22%). Men were more likely to have intracranial lesions than women (29% versus 14%, P=03).
When multivariate logistic regression analysis was used, white race was the only predictor for extracranial carotid artery lesions, and male sex was the only predictor for intracranial lesions. (...)
Mots-clés Pascal : Accident cérébrovasculaire, Athérosclérose, Prévalence, Intracrânien, Race, Sexe, Facteur risque, Extracrânien, Epidémiologie, Homme, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Cérébrovasculaire pathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie
Mots-clés Pascal anglais : Stroke, Atherosclerosis, Prevalence, Intracranial, Race, Sex, Risk factor, Extracranial, Epidemiology, Human, Nervous system diseases, Central nervous system disease, Cerebral disorder, Cerebrovascular disease, Cardiovascular disease, Vascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0015747
Code Inist : 002B30A01A2. Création : 21/05/1997.