Background The familial aggregation of coronary heart disease can be in large part accounted for by a clustering of cardiovascular disease risk factors.
To elucidate the determinants of cardiovascular disease, many epidemiological studies have focused on the behavioral and lifestyle determinants of these risk factors, whereas others have examined whether specific candidate genes influence quantitative variation in these phenotypes.
Methods and Results Among Mexican Americans from San Antonio (Tex), we quantified the relative contributions of both genetic and environmental influences to a large panel of cardiovascular risk factors, including serum levels of lipids, lipoproteins, glucose, hormones, adiposity, and blood pressure.
Members of 42 extended families were studied, including 1236 first-second-and third-degree relatives of randomly ascertained probands and their spouses.
In addition to the phenotypic assessments, information was obtained regarding usual dietary and physical activity patterns, medication use, smoking habits, alcohol consumption, and other lifestyle behaviors and medical factors.
Maximum likelihood methods were used to partition the variance of each phenotype into components attributable to the measured covariates, additive genetic effects (heritability), household effects, and an unmeasured environmental residual. (...)
Mots-clés Pascal : Cardiopathie coronaire, Alimentation, Qualité vie, Facteur risque, Déterminisme génétique, Epidémiologie, Homme, Etats Unis, Amérique du Nord, Amérique, Etude familiale, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Coronary heart disease, Feeding, Quality of life, Risk factor, Genetic inheritance, Epidemiology, Human, United States, North America, America, Family study, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0014370
Code Inist : 002B12A03. Création : 21/05/1997.