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  1. Benefits of continued cyclosporine through an indigent drug program.

    Article - En anglais

    Financial circumstances force some stable renal transplant recipients to discontinue cyclosporine (CsA).

    Previous results from our center document a subgroup of these patients at increased risk for acute rejection and allograft loss, namely, those of African ancestry.

    After 1988, such disadvantaged recipients have been able to receive CsA at no charge through the National Organization for Rare Disorders (NORD).

    At the University of Alabama at Birmingham, 54 patients were enrolled in the NORD program between 1988 and 1994.

    Acute rejection, allograft survival, and patient survival in these patients were compared with those in 42 patients who, prior to 1988, were withdrawn from CsA for financial reasons.

    Both groups were similar socioeconomically.

    The mean follow-up was 69 ± 33 months (±SD) in the withdrawal group and 45 ± 14 months in those entering the NORD program.

    Acute rejections occurred with similar frequency in both groups before CsA withdrawal (45%) or NORD enrollment (48%). In contrast, acute rejections were more common in patients after the onset of CsA withdrawal (38%) than after NORD enrollment (11%) (P<0.01).

    Black patients withdrawn from CsA experienced more acute rejections than their counterparts in the NORD program (57% v 15%) (P<0.01).

    White NORD recipients also experienced fewer acute rejections, although the difference was not statistically significant (withdrawal group 16% v NORD group 4% ; P=0.29). (...)

    Mots-clés Pascal : Insuffisance rénale, Homotransplantation, Rein, Ciclosporine, Statut socioéconomique, Rejet, Greffon, Traitement, Prévention, Complication, Ethnie, Etats Unis, Amérique du Nord, Amérique, Appareil urinaire pathologie, Rein pathologie, Transplantation, Chirurgie, Chimiothérapie, Immunomodulateur

    Mots-clés Pascal anglais : Renal failure, Homotransplantation, Kidney, Ciclosporin, Socioeconomic status, Rejection, Graft(material), Treatment, Prevention, Complication, Ethnic group, United States, North America, America, Urinary system disease, Kidney disease, Transplantation, Surgery, Chemotherapy, Immunomodulator

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0014170

    Code Inist : 002B02Q. Création : 21/05/1997.