Previously, we found a decrease in CD4+CD45RA+T lymphocytes in workers exposed to the aromatic amines (AAs) [benzidine (BZ) and beta naphthylamine (BNA) ]. For further investigation of the effects of AAs on lymphocyte subpopulations, we measured natural killer (NK) cell subpopulations using two-color staining with anti-Leu7 (CD57) and anti-Leu11 (CD16) monoclonal antibodies in peripheral blood in 78 male dyestuff workers.
The workers had been exposed to AAs before 1972 at a chemical plant, either in the production of AAs (40 workers, high-exposure group) or in other work that involved handling dyestuffs (38 workers, low-exposure group).
The controls were 30 « healthy » male volunteers without a history of occupational exposure to AAs or hazardous chemicals.
The number of CD57+CD16 - cells in the high-exposure group was significantly higher than that in the controls (P<0.01, analysis of covariance with age as a covariate).
No significant differences were found in CD57+CD16 - CD57+CD16+and CD57 - CD16+NK cells between the low-exposure group and the controls.
It is suggested that a decrease in the number of CD4+T lymphocytes following exposure to AAs might be compensated by the increase in CD57+CD16 - cells, i.e. circulating peripheral lymphocytes with poor NK cell activity.
Mots-clés Pascal : Benzidine, Carcinogène, Exposition professionnelle, Toxicité, Homme, Lymphocyte T, Amine, Composé aromatique, Cellule NK, Sous population cellulaire, Médecine travail, 2-naphtylamine, Antigène CD57, Antigène CD16
Mots-clés Pascal anglais : Benzidine, Carcinogen, Occupational exposure, Toxicity, Human, T-Lymphocyte, Amine, Aromatic compound, Natural killer cell, Cell subpopulation, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0009274
Code Inist : 002B04E02. Création : 21/05/1997.