Urinary hexane diamine as an indicator of occupational exposure to hexamethylene diisocyanate.
The occupational exposure of 19 men to hexamethylene diisocyanate (HDI) vapour was monitored during one 8-h shift.
It ranged from 0.30 to 97.7 mug/m3.
This was compared with the urinary output of hexane diamine (HDA) liberated by acid hydrolysis from its conjugates in post-shift samples.
The excretion varied from 1.36 to 27.7 mug/g creatinine, and therc was a linear association of HDI air concentration with urinary HDA excretion.
The validity of the urinary analysis was confirmed by simultaneous blind analysis in another laboratory.
The results had an excellent linear concordance.
Thus, it seems that while the gas chromatographic mass spectrometric detection method requires sophisticated apparatus, the results are very useful to occupational health practices.
A biological exposure index limit of 19 mug HDA/g creatinine in a post-shift urine specimen is proposed as an occupational limit level of HDI monomer (time-weighted average=75 mug/m3).
Most importantly, biological monitoring of HDA is sensitive enough to be used at and below the current allowable exposure limit levels.
Mots-clés Pascal : Diisocyanate organique, Isocyanate organique, Exposition professionnelle, Surveillance biologique, Marqueur biologique, Urine, Homme, Vapeur, Médecine travail, Héxane(1,6-diisocyanato)
Mots-clés Pascal anglais : Organic diisocyanate, Organic isocyanate, Occupational exposure, Biological monitoring, Biological marker, Urine, Human, Vapor, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0009273
Code Inist : 002B03L06. Création : 21/05/1997.