Objective The aim of the study was to examine whether an increase can be detected in the prevalence of coronary heart disease or a higher prevalence of unusual cardiological findings in workers with occupational exposure to carbon disulphide (CS2) at the level of the threshold limit value of 10 ppm currently valid in occupational medicine.
Methods In a cross-sectional study we investigated 247 men occupationally exposed to CS2 and a comparable control group (n=222).
The current exposure to CS2 was measured using personal air monitoring and biological monitoring of all test persons.
A cumulative exposure index (median of CS2 exposure in the past multiplied by the duration of employment) was calculated.
In addition to collecting comprehensive anamnestic data on all persons, we carried out a physical examination, an ultrasound examination of the large arteries, a resting and exercise ECG and an echocardiographic examination.
Results No increase could be found in the prevalence of coronary heart disease or of arteriosclerotic findings in the exposed subjects.
There was no difference in the distribution of the performance of the two groups in the ergometric tests.
The echocardiogram showed a median increase in the diameter of the left atrium and left ventricle of 1-2mm in the exposed subjects.
These differences could also be confirmed statistically after multiple linear regression analysis.
The left ventricular, telesystolic diameter was positively associated (P<0. (...)
Mots-clés Pascal : Carbone disulfure, Exposition professionnelle, Toxicité, Cardiopathie coronaire, Homme, Epidémiologie, Bicyclette ergométrique, Echocardiographie, Electrocardiographie, Médecine travail, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Carbon disulfide, Occupational exposure, Toxicity, Coronary heart disease, Human, Epidemiology, Bicycle ergometer, Echocardiography, Electrocardiography, Occupational medicine, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0009268
Code Inist : 002B03L05. Création : 21/05/1997.