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  1. Performance characteristics and results of a large-scale screening program for viral hepatitis and risk factors associated with exposure to viral hepatitis B and C : Results of the national hepatitis screening survey.

    Article - En anglais

    Chronic viral hepatitis frequently goes undetected until cirrhosis develops.

    Although the effect of interferon on the natural history of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection in asymptomatic persons is unknown, treatment may modify the course of the infection, producing cures in some.

    In September 1992, screening for HBV and HCV was offered in 40 centers throughout the United States.

    Demographic features, potential risk factors, and symptoms were studied.

    Blood samples were obtained for the determination of serum alanine aminotransferase levels and for markers of HBV and HCV infection.

    Thirteen thousand nine hundred ninety seven subjects were screened.

    The prevalence of infection with HBV or HCV was 24.8% (HBV 17.8% ; HCV 7.0% ; and both 2.8%). Hepatitis B and C disease was present in 0.7% and 4.4% of the population, respectively.

    Risk factors for HBV and HCV infection were similar in : blood transfusions, hemodialysis, IV drug use, and sex with an IV drug user.

    For HBV infection, sex with multiple partners, increasing age, and birth in South East Asia or Africa were additional risk factors.

    The cost to find a case of HCV infection is less than the costs for finding many other treatable diseases.

    Screening for HBV, though more costly, is reasonably efficient, and simultaneous screening for HBV and HCV provides greater efficiency. (...)

    Mots-clés Pascal : Hépatite virale B, Virose, Infection, Hépatite virale C, Facteur risque, Complication, Dépistage, Exploration immunologique, Virus hépatite B, Hepadnaviridae, Virus, Virus hépatite C, Flaviviridae, Epidémiologie, Homme, Etats Unis, Amérique du Nord, Amérique, Appareil digestif pathologie, Foie pathologie

    Mots-clés Pascal anglais : Viral hepatitis B, Viral disease, Infection, Viral hepatitis C, Risk factor, Complication, Medical screening, Immunological investigation, Hepatitis B virus, Hepadnaviridae, Virus, Hepatitis C virus, Flaviviridae, Epidemiology, Human, United States, North America, America, Digestive diseases, Hepatic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0008974

    Code Inist : 002B05C02G. Création : 21/05/1997.