The effects of exposure to solvents on serum bile acids were investigated by comparing a group of apprentice vehicle spray painters (exposed group) with one of apprentice electricians.
Apprentice spray painters from the study were subdivided into high-and low-solvent-exposure groups.
Concentrations of individual serum bile acids (SBA) were measured and compared with conventional liver function tests (LFTs).
Total, free. glycine-and taurine-conjugated SBA were consistently found to be present at higher levels in the spray painters than in the electricians, even at the beginning of the apprenticeship.
Total SBA tended to increase in spray painters with increasing years of exposure during the apprenticeship, but this was significant at only one time point.
No rises were observed over the sampling period in electricians.
The mean values of individual and total SBA concentrations were all found to be higher in the high-exposure group than in the low-exposure group, with some differences reaching statistical significane.
None of the routine liver biochemistry parameters was different between spray painters and electricians. gamma-Glutamyl transferase (GGT) was the only enzyme found to be significantly different between the high-and low-exposure groups, but all values were within the normal range.
This study suggests that occupational exposure even to low levels of solvent mixtures results in increases in SBA. (...)
Mots-clés Pascal : Solvant organique, Exposition professionnelle, Toxicité, Acide biliaire, Sérum, Peintre en bâtiment, Homme, Foie pathologie, Relation dose réponse, Médecine travail, Pulvérisation, Appareil digestif pathologie
Mots-clés Pascal anglais : Organic solvent, Occupational exposure, Toxicity, Bile acid, Serum, House painter, Human, Hepatic disease, Dose activity relation, Occupational medicine, Spraying, Digestive diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0008724
Code Inist : 002B03L04. Création : 21/05/1997.