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  1. Antidepressant-treated patients in ambulatory care : Mortality during a nine-year period after first treatment.

    Article - En anglais


    Non-institutionalised patients treated with antidepressants have been shown to have indicators of a generalised vulnerability, such as high rates of health service use and excessive prescription drug use.

    Therefore, mortality in this patient group is of interest.


    All first-incidence antidepressant users in a defined population during a five-year period were identified.

    Their total mortality during a nine-year follow-up was analysed.

    Cox proportional hazards regression was used to analyse total mortality, and mortality in cardiovascular disease, controlling for baseline chronic medical disease.


    Antidepressant treatment at the index date was a statistically significant predictor for increased long-term mortality in the over-65s, even when controlling for pre-existing chronic medical disease.

    Baseline ischaemic heart disease and concurrent antidepressant treatment significantly predicted mortality from cardiovascular causes.


    Prescribed antidepressant treatment identifies patients who are at risk of increased mortality.

    For the physician in ambulatory care, knowledge of a patient's antidepressant treatment history may be a valuable tool in managing patient care.

    Mots-clés Pascal : Etat dépressif, Trouble humeur, Ambulatoire, Soin, Chimiothérapie, Traitement, Antidépresseur, Psychotrope, Etude longitudinale, Mortalité, Facteur risque, Prédiction, Homme

    Mots-clés Pascal anglais : Depression, Mood disorder, Ambulatory, Care, Chemotherapy, Treatment, Antidepressant agent, Psychotropic, Follow up study, Mortality, Risk factor, Prediction, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0005593

    Code Inist : 002B02B02. Création : 21/05/1997.