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  1. Priming with diphtheria-tetanus-pertussis vaccine enhances the response to the Haemophilus influenzae type b tetanus conjugate vaccine in infancy.

    Article - En anglais

    Haemophilus influenzae type b (Hib) capsular polysaccharide (PS) conjugated to tetanus toxoid (PRP-T) was given at 4 and 6 months of age and anti-Hib PS antibody response to the first and second dose of PRP-T was compared in groups that received diphtheria-tetanus-pertussis (DTP) vaccine either simultaneously with PRP-T (34 infants) or separately at 3,4 and 5 months of age (49 infants).

    The geometric mean anti-Hib PS antibody concentration after the first dose of PRP-T given at 4 months of age was eightfold higher if the infants primed with DTP at 3 months of age than if the first dose of DTP was given together with the first dose of PRP-T (0.81 mug ml-1 vs 0.11 mug ml-1).

    The positive influence of DTP priming was seen also after the second dose of PRP-T given at 6 months of age (7.55 mug ml-1 vs 3.45 mug ml-1).

    Mots-clés Pascal : Calendrier vaccination, Haemophilus influenzae, Pasteurellaceae, Bactérie, Composé conjugué, Anatoxine, Tétanos, Bactériose, Infection, Immunisation, Vaccin associé, Diphtérie, Coqueluche, Nourrisson, Homme, Immunogénicité, Immunité humorale, Réponse immune

    Mots-clés Pascal anglais : Vaccination schedule, Haemophilus influenzae, Pasteurellaceae, Bacteria, Conjugated compound, Toxoid, Tetanus, Bacteriosis, Infection, Immunization, Mixed vaccine, Diphtheria, Whooping cough, Infant, Human, Immunogenicity, Humoral immunity, Immune response

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0004209

    Code Inist : 002B05A02. Création : 21/05/1997.