Priming with diphtheria-tetanus-pertussis vaccine enhances the response to the Haemophilus influenzae type b tetanus conjugate vaccine in infancy.
Haemophilus influenzae type b (Hib) capsular polysaccharide (PS) conjugated to tetanus toxoid (PRP-T) was given at 4 and 6 months of age and anti-Hib PS antibody response to the first and second dose of PRP-T was compared in groups that received diphtheria-tetanus-pertussis (DTP) vaccine either simultaneously with PRP-T (34 infants) or separately at 3,4 and 5 months of age (49 infants).
The geometric mean anti-Hib PS antibody concentration after the first dose of PRP-T given at 4 months of age was eightfold higher if the infants primed with DTP at 3 months of age than if the first dose of DTP was given together with the first dose of PRP-T (0.81 mug ml-1 vs 0.11 mug ml-1).
The positive influence of DTP priming was seen also after the second dose of PRP-T given at 6 months of age (7.55 mug ml-1 vs 3.45 mug ml-1).
Mots-clés Pascal : Calendrier vaccination, Haemophilus influenzae, Pasteurellaceae, Bactérie, Composé conjugué, Anatoxine, Tétanos, Bactériose, Infection, Immunisation, Vaccin associé, Diphtérie, Coqueluche, Nourrisson, Homme, Immunogénicité, Immunité humorale, Réponse immune
Mots-clés Pascal anglais : Vaccination schedule, Haemophilus influenzae, Pasteurellaceae, Bacteria, Conjugated compound, Toxoid, Tetanus, Bacteriosis, Infection, Immunization, Mixed vaccine, Diphtheria, Whooping cough, Infant, Human, Immunogenicity, Humoral immunity, Immune response
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0004209
Code Inist : 002B05A02. Création : 21/05/1997.