Levels of PCDD/PCDF in blood fat as indices of the PCDD/PCDF body burden in humans.
European Meeting of Environmental Hygiene. Prague (CZE), 1995/06/27.
The levels of PCDD/F in blood fat are similar to those in body fat and in milk fat of lactating women.
Therefore, the levels of PCDD/F in blood fat can be used as an index of the individual PCDD/F body burden in humans.
In order to evaluate the PCDD/F background exposure levels of the German population, blood samples collected from 95 subjects (age 12-82 years) living in a rural area of North-West Germany were analysed for PCDD/F. The median 2,3,7,8-TCDD toxicity equivalents (TE) were 40.8 pg I-TE/g blood fat and the 95th percentile was 82.1 pg I-TE/g blood fat.
The TE levels in blood fat show a marked increase with age, which reflects the pronounced accumulation of PCDD/F in the human body throughout the entire lifetime.
Considering single congeners, significant differences in the age-related increase were noted.
Using age-specific reference values derived from this study the levels of PCDD/F in blood fat of individuals environmentally exposed to PCDD/F under different circumstances were evaluated.
Mots-clés Pascal : Accumulation biologique, Surveillance biologique, Globule lipidique, Sang total, Liquide biologique, Lait maternel, Homme, Polluant, Dibenzo-p-dioxine(polychloro), Dibenzofurane(polychloro), Chlore Composé organique, Allemagne, Europe, Zone rurale, Evaluation risque, Analyse corrélation, Age, Poids corporel
Mots-clés Pascal anglais : Biological accumulation, Biological monitoring, Fat globule, Whole blood, Biological fluid, Breast milk, Human, Pollutant, Chlorine Organic compounds, Germany, Europe, Rural area, Risk assessment, Correlation analysis, Age, Body weight
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0004176
Code Inist : 002B03L06. Création : 21/05/1997.