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  1. Biological monitoring of pyrethroid metabolites in urine of pest control operators.

    Article, Communication - En anglais

    European Meeting of Environmental Hygiene. Prague (CZE), 1995/06/27.

    Due to their low mammalian toxicity but high insectical activity, pyrethroids are increasingly used for pest control.

    The objective of the present study was the development of a biological monitoring program to determine exposure to pyrethroids.

    A diastereoselective detection of the major pyrethroid metabolites cis-and trans-3- (2,2-dichlorovinyl) - 2,2-dimethylcyclopropanecarboxylic acid, cis-3- (2,2-dibromovinyl) - 2,2-dimethylcyclopropanecarboxylic acid, 3-phenoxybenzoic acid and fluorophenoxybenzoic acid by capillary gas chromatography in combination with mass selective detection was applied.

    The limits of determination ranged between 0.5 and 1 mug/l urine, depending on the metabolite concerned.

    It was demonstrated that pyrethroid metabolites were detectable in urine for a period of elimination up to 3.5 days after exposure to cyfluthrin.

    Fluorophenoxybenzoic acid was shown to be a suitable biomarker for exposure to cyfluthrin.

    The presented method was adequate for monitoring pyrethroids in occupationally exposed subjects.

    Mots-clés Pascal : Surveillance biologique, Analyse chimique, Analyse quantitative, Métabolite, Pesticide, Insecticide, Pyréthrinoïde, Elimination, Homme, Exposition professionnelle, Médecine travail, Urine, Liquide biologique, Marqueur biologique, Chromatographie phase gazeuse, Benzoïque acide(4-fluoro-3-phénoxy) ester méthyle, Benzoïque acide(3-phénoxy) ester méthyle, Cyclopropanecarboxylique acide(2-[2,2-dichlorovinyl]-3,3-diméthyl) ester méthyle, Cyclopropanecarboxylique acide(2-[2,2-dibromovinyl]-3,3-diméthyl) ester méthyle

    Mots-clés Pascal anglais : Biological monitoring, Chemical analysis, Quantitative analysis, Metabolite, Pesticides, Insecticide, Pyrethroids, Elimination, Human, Occupational exposure, Occupational medicine, Urine, Biological fluid, Biological marker, Gas chromatography

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0002773

    Code Inist : 002B03G. Création : 21/05/1997.