Cytogenetic studies in coke oven workers.
European Meeting of Environmental Hygiene. Prague (CZE), 1995/06/27.
Chromosome aberrations, micronuclei, and sister chromatid exchanges (SCE) were evaluated in cultured lymphocytes of coke oven workers of an Italian steel industry plant, occupationally exposed to polycyclic aromatic hydrocarbons, and in a group of unexposed controls from a non-oven plant in the same area.
No differences were found between exposed and controls for rates of total abnormal metaphases (including and excluding gaps), chromatid-type and chromosome-type aberrations, cells with 2 or more breaks, and for micronuclei.
On the contrary, SCE were significantly increased in the exposed versus the controls, but, when smoking habits were considered, the increase was significant only for smokers.
Mots-clés Pascal : Toxicité, DNA, Carcinogène, Médecine travail, Exposition professionnelle, Italie, Europe, Inhalation, Gaz cokerie, Polluant, Composé aromatique polycyclique, Aciérie, Homme, Méthode étude, Culture cellulaire, Lymphocyte, Aberration chromosomique, Echange chromatide soeur, Micronucléus, Fumeur, Non fumeur, Marqueur biologique
Mots-clés Pascal anglais : Toxicity, DNA, Carcinogen, Occupational medicine, Occupational exposure, Italy, Europe, Inhalation, Coke oven gas, Pollutant, Polycyclic aromatic compound, Steelmaking plant, Human, Investigation method, Cell culture, Lymphocyte, Chromosomal aberration, Sister chromatid exchange, Micronucleus, Smoker, Non smoker, Biological marker
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0002769
Code Inist : 002B04E02. Création : 21/05/1997.