Epidemiology, serological markers, and hepatic disease of anti-HCV ELISA-2-positive blood donors.
The epidemiology associated with hepatitis C virus (HCV) infection, serologic reactivity, and hepatic disease related to anti-HCV-positive donors of Granada were researched.
From 1990 through 1993, medical and epidemiological information and anti-HCV and HCV RNA testing were evaluated in 46,741 blood donors.
Serum samples were obtained for anti-HCV ELISA and RIBA and HCV RNA determination.
A liver biopsy was conducted in all anti-HCV positives by confirmatory second-generation RIBA to analyze the hepatic lesion and the presence of HCV RNA.
The anti-HCV prevalence was 1.12%. A total of 228 anti-HCV second-generation ELISA positive blood donors were analyzed.
Intrafamiliar transmission rate was 1.7%. Transfusion and intravenous drug abuse (IVDA) antecedents were associated with a higher risk of seroconversion.
A RIBA-positive result was related to high second-and third-generation ELISA ratios (90%), HCV RNA positivity (89%), and elevated alanine aminotransferase (ALT) levels (88%). Approximately 50% of donors with normal ALT levels had high ELISA ratios and second-generation RIBA and HCV RNA positive results.
Of the second-generation RIBA indeterminate results, 42% and 82% of the c22 and 33% and 100% of the c100 reactivities were third-generation RIBA and HCV RNA positive, respectively.
Liver biopsy was conducted in 85 donors, 74% of whom had a chronic hepatitis and 83% had detectable HCV RNA levels. (...)
Mots-clés Pascal : Donneur sang, Séropositivité, Anticorps, Virus hépatite C, Flaviviridae, Virus, Exploration immunologique, Technique ELISA, Epidémiologie, Marqueur biologique, RNA, Hépatite virale C, Virose, Infection, Etude cohorte, Homme, Espagne, Europe, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Blood donor, Seropositivity, Antibody, Hepatitis C virus, Flaviviridae, Virus, Immunological investigation, ELISA assay, Epidemiology, Biological marker, RNA, Viral hepatitis C, Viral disease, Infection, Cohort study, Human, Spain, Europe, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0000655
Code Inist : 002B05C02G. Création : 21/05/1997.