This nested case-control study assessed the relationship between a woman's age at the time of her initial primary breast or ovarian cancer diagnosis and the risk of a second primary cancer at the other of these two sites.
Multiple primary breast and ovarian cancer cases whose initial breast or ovarian diagnosis occurred in 1970-1989 and a random sample of single primary breast or ovarian cancer controls diagnosed in the same years were identified through tumor registries at Duke University Medical Center and the University of North Carolina.
Women diagnosed with an initial primary breast cancer at age ¾ 50 years were 4.3 times (95% CI : 1.8-10.6) more likely to have developed a subsequent ovarian cancer compared to those diagnosed after age 50.
A relationship between an early age at diagnosis (¾ 50) of ovarian cancer and subsequent diagnosis of breast cancer was not found (odds ratio (OR)=0.6 ; 95% CI : 0.2-2.0).
Adjustment for stage at diagnosis, treatment, year of diagnosis and length of follow-up using Cox Proportional Hazards modeling techniques supported these relationships, yielding a hazard ratio (HR) for the development of a second primary cancer at the alternate site of 4.6 (95% CI : 1.8-11.5) for women with an initial breast cancer diagnosis and 0.6 (95% CI : 0.2-2.2) for women with an initial ovarian cancer diagnosis. (...)
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Ovaire, Homme, Femelle, Etude cohorte, Epidémiologie, Age, Diagnostic, Facteur risque, Glande mammaire pathologie, Ovaire pathologie, Appareil génital femelle pathologie, Caroline du Nord, Etats Unis, Amérique du Nord, Amérique, Tumeur multiple
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Ovary, Human, Female, Cohort study, Epidemiology, Age, Diagnosis, Risk factor, Mammary gland diseases, Ovarian diseases, Female genital diseases, North Carolina, United States, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0506702
Code Inist : 002B20E02. Création : 10/04/1997.