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  1. Ultraviolet light and non-Hdgkin's lymphoma.

    Article - En anglais

    In the beginning of this century, a Danish dermatologist, Professor Niels Finsen, received the Nobel Prize for his showing of the beneficial effects of UV-light on certain skin diseases.

    We have subsequently learned that UV-light is far from being only beneficial to our health.

    UV-light is an important risk factor for malignant melanoma and squamous cell carcinoma of the skin (1).

    Furthermore, UV-light appears to have immunosuppressive effects, not only on the local skin, but on the immune system in general (2-4).

    Recently, it was suggested that UV-light may also increase the risk of non-Hodgkin's lymphoma (NHL) (5,6).

    Studies on the cause (s) of the universal rise in NHL incidence have become increasingly intense.

    Evident in both industrialized and developing countries throughout the latest 2-3 decades, the rise is apparent since the 1930's and 1940's in countries with long traditions of cancer registration (5,7-11).

    The observed increase cannot be explained by factors such as changes in classification, in diagnostic procedures and in therapeutic measures available alone.

    Recently, Hartge & Devesa (12) estimated that taking such factors into consideration, an 80% of the increase in NHL incidence remained unaccounted for.

    This universal increase in NHL, unparalleled in cancer epidemiology, suggests that exposure to the underlying factor (s) must be generally increasing in human populations.

    Currently known risk factors offer no satisfactory explanation for the increase.

    Mots-clés Pascal : Lymphome non hodgkinien, Facteur risque, Epidémiologie, Rayonnement UV, Rayonnement solaire, Homme, Hémopathie maligne, Lymphoprolifératif syndrome

    Mots-clés Pascal anglais : Non Hodgkin lymphoma, Risk factor, Epidemiology, Ultraviolet radiation, Solar radiation, Human, Malignant hemopathy, Lymphoproliferative syndrome

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0505223

    Code Inist : 002B19B. Création : 10/04/1997.