Background Depression is associated with alterations in behavior and neuroendocrine systems that are risk factors for decreased bone mineral density.
This study was undertaken to determine whether women with past or current major depression have demonstrable decreases in bone density.
Methods We measured bone mineral density at the hip, spine, and radius in 24 women with past or current major depression and 24 normal women matched for age, body-mass index, menopausal status, and race, using dual-energy x-ray absorptiometry.
We also evaluated cortisol and growth hormone secretion, bone metabolism, and vitamin D-receptor alleles.
Results As compared with the normal women, the mean (±SD) bone density in the women with past or current depression was 6.5 percent lower at the spine (1.00±0.15 vs. 1.07±0.09 g per square centimeter, P=0.02), 13.6 percent lower at the femoral neck 10.76 ± 0.11 vs. 0.88±0.11 per square centimeter, P<0.001), 13.6 percent lower at Ward's triangle (0.70±0.14 vs. 0.81 ± 0.13 g per square centimeter, P<0.001), and 10.8 percent lower at the trochanter (0.66±0.11 vs. 0.74±0.08 g per square centimeter, P<0.001).
In addition, women with past or current depression had higher urinary cortisol excretion (71±29 vs. 51±19 mug per day [196±80 vs. 141±52 nmol per day], P=0.006), lower serum osteocalcin concentrations (P=0.04), and lower urinary excretion of deoxypyridinoline (P=0.02). (...)
Mots-clés Pascal : Etat dépressif, Densité, Os, Masse osseuse, Epidémiologie, Facteur risque, Femme, Homme, Etude comparative, Trouble humeur, Système ostéoarticulaire pathologie
Mots-clés Pascal anglais : Depression, Density, Bone, Bone mass, Epidemiology, Risk factor, Woman, Human, Comparative study, Mood disorder, Diseases of the osteoarticular system
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0502366
Code Inist : 002B15A. Création : 10/04/1997.