We report the clinical features, electrophysiological studies, sural nerve pathology and recovery course of carbon disulfide- (CS2) induced polyneuropathy in a 48-year-old man who worked in a viscose rayon plant.
Sural nerve biopsy 2 years later still showed degeneration of both axon and myelin with a predominant loss of large myelinated fibers and remyelination.
Electrophysiologic studies revealed mixed axonal and demyelinating polyneuropathy.
To our knowledge, this is the first human report of sural nerve pathology in the recovery stage due to CS2 intoxication.
After diagnosis, the patient was removed from the toxic environment.
In the following three years, he showed part recovery predominantly in motor function compatible with the serial nerve conduction studies.
We conclude that CS2 polyneuropathy may partly recover years after cessation of exposure.
Mots-clés Pascal : Polyneuropathie périphérique, Nerf saphène externe, Carbone disulfure, Toxicité, Exposition professionnelle, Electrophysiologie, Médecine travail, Diagnostic, Homme, Etude cas, Système nerveux pathologie, Nerf périphérique pathologie, Solvant organique
Mots-clés Pascal anglais : Polyneuropathy, Sural nerve, Carbon disulfide, Toxicity, Occupational exposure, Electrophysiology, Occupational medicine, Diagnosis, Human, Case study, Nervous system diseases, Peripheral nerve disease, Organic solvent
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0502157
Code Inist : 002B03L04. Création : 10/04/1997.