The authors reviewed the medical records of 194 human immunodeficiency virus (HIV) - positive patients newly diagnosed with cryptosporidiosis and all 3,564 patients with newly diagnosed acquired immunodeficiency syndrome (AIDS) at San Francisco General Hospital for the period 1986-1992.
The study was designed to address three questions : 1) How do AIDS patients who present with cryptosporidiosis differ from other patients with AIDS ? 2) What factors are associated with survival among AIDS patients with newly diagnosed cryptosporidiosis ? 3) Does a diagnosis of cryptosporidiosis impact survival after AIDS diagnosis ?
A total of 194 cases of cryptosporidiosis among HIV-infected patients were identified during the study period.
Of the 194 patients, 109 (56%) had no prior diagnosis of AIDS.
These 109 patients represented 3.1% of the 3,564 newly diagnosed cases of AIDS in the same period.
Among the 134 patients with CD4 T-lymphocyte counts performed within 3 months of Cryptosporidium diagnosis, 34 (25%) had CD4 counts greater than 209 cells/ml.
In a multivariate conditional logistic regression model, the incidence of Cryptosporidium was related to ethnicity (for blacks vs. whites, matched odds ratio (OR)=0.15,95% confidence interval (CI) 0.03-0.73), CD4 count (for a CD4 count of ¾53 cells/ml vs.>53 cells/ml, matched OR=12.60,95% CI 4.01-39.61), and age (for a 10-year increase, matched OR=0.51,95% CI 0.27-0.98). (...)
Mots-clés Pascal : SIDA, Virose, Infection, Cryptosporidiose, Protozoose, Parasitose, Association, Homme, Epidémiologie, Survie, Facteur risque, Etats Unis, Amérique du Nord, Amérique, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Cryptosporidiosis, Protozoal disease, Parasitosis, Association, Human, Epidemiology, Survival, Risk factor, United States, North America, America, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0499071
Code Inist : 002B06D01. Création : 10/04/1997.