Background Although the incidence of Lyme disease is highest in children, there are few prospective data on the clinical manifestations and outcomes in children.
Methods We conducted a prospective, longitudinal, community-based cohort study of children with newly diagnosed Lyme disease in an area of Connecticut in which the disease is highly endemic.
We obtained clinical and demographic information and performed serial antibody tests and follow-up evaluations.
Results Over a period of 20 months, 201 consecutive patients were enrolled ; their median age was 7 years (range, 1 to 21).
The initial clinical manifestations of Lyme disease were a single erythema migrans lesion in 66 percent, multiple erythema migrans lesions in 23 percent, arthritis in 6 percent, facial-nerve palsy in 3 percent, aseptic meningitis in 2 percent, and carditis in 0.5 percent.
At presentation, 37 percent of the patients with a single erythema migrans lesion and 89 percent of those with multiple erythema migrans lesions had antibodies against Borrelia burgdorferi.
All but 3 of the 201 patients were treated for two to four weeks with conventional antimicrobial therapy, which was administered orally in 96 percent.
All had prompt clinical responses.
After four weeks, 94 percent were completely asymptomatic (including the two patients whose parents had refused to allow antimicrobial treatment).
At follow-up a mean of 25. (...)
Mots-clés Pascal : Lyme maladie, Borréliose, Spirochétose, Bactériose, Infection, Dépistage, Epidémiologie, Incidence, Diagnostic, Erythème nécrotique migrant, Traitement, Symptomatologie, Enfant, Homme, Pronostic, Connecticut, Etats Unis, Amérique du Nord, Amérique, Américain
Mots-clés Pascal anglais : Lyme disease, Borrelia infection, Spirachaetosis, Bacteriosis, Infection, Medical screening, Epidemiology, Incidence, Diagnosis, Necrotic migrans erythema, Treatment, Symptomatology, Child, Human, Prognosis, Connecticut, United States, North America, America, American
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0494035
Code Inist : 002B05B02L6. Création : 10/04/1997.