Cigarette smoking is associated with a reduction in the risk for endometrial cancer in post-menopausal women and it has been suggested that this is because smoking has an anti-oestrogenic effect.
To investigate this, concentrations of oestrone, oestradiol and oestriol were measured in 24 h urine samples from 167 premenopausal women (53 smokers, 114 non-smokers) and 200 post-menopausal women (54 smokers, 146 non-smokers).
Among premenopausal women there were no significant differences in oestrogen excretion between smokers and non-smokers.
Among post-menopausal women, geometric mean excretion rates for oestrone and oestradiol did not differ significantly between groups, but oestriol excretion was 19% lower (95% confidence interval - 34% to - 1%) in smokers than in non-smokers.
This may partly explain the reduced risk for endometrial cancer among post-menopausal smokers.
Mots-clés Pascal : Tumeur maligne, Endomètre, Facteur risque, Epidémiologie, Tabagisme, Oestrone, Oestradiol, Urine, Postménopause, Préménopause, Royaume Uni, Europe, Homme, Appareil génital femelle pathologie, Utérus pathologie, Oestrogène, Hormone stéroïde sexuelle, Hormone ovarienne, Ile Guernesey
Mots-clés Pascal anglais : Malignant tumor, Endometrium, Risk factor, Epidemiology, Tobacco smoking, Estrone, Estradiol, Urine, Postmenopause, Premenopause, United Kingdom, Europe, Human, Female genital diseases, Uterine diseases, Estrogen, Sex steroid hormone, Ovarian hormone
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0493801
Code Inist : 002B20C02. Création : 10/04/1997.