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  1. Clinical presentation of (subclinical) jaundice : The Euricterus Project in The Netherlands.

    Article - En anglais

    Background 

    From a primary clinical database, we wanted to obtain insight in disease distribution and clinical presentation of adult jaundiced patients in a Western country.

    Materials and Methods 

    As part of the Euricterus project, 24 Dutch general and academic hospitals in a period of 2 years gathered prospectively 702 patients on a standard proforma.

    Patient aged 16 years or more (median 61) and with a serum bilirubin of 20mmol/l or more (median 83) were included.

    The final diagnosis was established within 3 months.

    Results Pancreatic or biliary carcinoma (20%), gallstone disease (13%) and alcoholic liver cirrhosis (10%) were the 3 most frequent diagnoses.

    Imaging (79%), clinical course (63%) and chemistry/serology (57%) were the most used ascertaining methods.

    Pancreatic or biliary carcinoma and gallstone disease were more common and age higher in general hospitals (p=0.0001), and'immunological'liver disease, non-alcoholic cirrhosis and hepatocellular carcinoma (HCC) more common in academic hospitals (p=0.001).

    Patients aged 90 years or older (13%) had pancreatic or biliary carcinoma, liver metastases or heart failure and patients with age less than 20 (0.9%) had acute viral hepatitis, non-alcoholic active liver disease or HCC.

    Risk factors were more apparent (p<0.02) in those aged less than 61 years. (...)

    Mots-clés Pascal : Ictère, Exploration clinique, Maladie, Incidence, Epidémiologie, Homme, Appareil digestif pathologie, Foie pathologie, Voie biliaire pathologie

    Mots-clés Pascal anglais : Jaundice, Clinical investigation, Disease, Incidence, Epidemiology, Human, Digestive diseases, Hepatic disease, Biliary tract disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0492614

    Code Inist : 002B30A01A2. Création : 10/04/1997.