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  1. Nonsteroidal antiinflammatory drug use and cognitive function in the elderly : Inconclusive results from a population-based cohort study.

    Article - En anglais

    As part of the cohort Paquid, we studied the relationship between the use of NSAID, incidence of dementia, and evolution of cognitive functions.

    Dementia was diagnosed by DSM-III criteria and cognitive functions was assessed through the Mini-Mental Status Examination (MMSE).

    During 2 years of follow-up, the incidence rate of dementia was 3.84% among 53 NSAID users as compared with 3.77% in 1199 nonusers (OR, 0.98 ; 95% CI, 0.23-4.16).

    Using a cutoff of - 3 points for the MMSE score and taking into account age and educational status in a logistic regression model, NSAID use was related to an unfavorable variation of the MMSE score (OR, 2.84 ; 95%, CI, 0.99-8.1).

    Mots-clés Pascal : Antiinflammatoire non stéroïde, Prévention, Démence sénile, Cognition, Vieillard, Homme, Epidémiologie, France, Europe, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Maladie dégénérative

    Mots-clés Pascal anglais : Non steroidal antiinflammatory agent, Prevention, Senile dementia, Cognition, Elderly, Human, Epidemiology, France, Europe, Nervous system diseases, Central nervous system disease, Cerebral disorder, Degenerative disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0489287

    Code Inist : 002B02B11. Création : 10/04/1997.