To compare therapeutic outcome and perform a cost-benefit analysis of inpatients with community-acquired pneumonia (CAP) treated with a shortened course of IV antibiotic therapy.
A prospective, randomized, parallel group study with a follow-up period of 28 days.
Bronx Veterans Affairs Medical Center (VAMC) and the Castle Point VAMC ; university-affiliated VAMC general medical wards from September 1993 to March 1995.
Seventy-two male veterans and 1 female veteran with 75 episodes of CAP defined by a new infiltrate on chest radiograph and either history or physical findings consistent with pneumonia.
Study population was 42% (31) black, 33% (24) white, and 25% (18) Hispanic.
Patients were randomized (1 : 1 : 1) to 1 of 3 treatment groups :
group 1 received 2 days of IV and 8 days of oral therapy ;
group 2 received 5 days of IV and 5 days of oral therapy ;
and group 3 received 10 days of IV therapy.
Antibiotics consisted of cefuroxime, 750 mg every 8 h for the IV course, and cefuroxime axetil, 500 mg every 12 h for the oral therapy.
No differences were found in the clinical course, cure rates, or resolution of chest radiograph abnormalities among the three groups.
A significant difference was found in the length of stay (LOS) among the three groups.
The mean ± SD LOS was 6±3 days in group 1,8±2 days in group 2, and 11 ± 1 days in group 3. (...)
Mots-clés Pascal : Pneumonie, Bactériose, Infection, Traitement, Chimiothérapie, Antibiotique, Voie intraveineuse, Optimisation, Temps traitement, Analyse coût, Résultat, Homme, Appareil respiratoire pathologie, Poumon pathologie, Economie santé
Mots-clés Pascal anglais : Pneumonia, Bacteriosis, Infection, Treatment, Chemotherapy, Antibiotic, Intravenous administration, Optimization, Processing time, Cost analysis, Result, Human, Respiratory disease, Lung disease, Health economy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0483459
Code Inist : 002B02S02. Création : 10/04/1997.