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  1. Epidemiology and outcome of Pseudomonas aeruginosa bacteremia, with special emphasis on the influence of antibiotic treatment : Analysis of 189 episodes.

    Article - En anglais

    Objective 

    To evaluate the trend in incidence of Pseudomonas aeruginosa bacteremia, underlying conditions of patients, mortality rate, and factors associated with poor outcome.

    Patients and Methods 

    Medical charts of 189 consecutive episodes of P aeruginosa bacteremia, detected between January 1,1991, and December 31,1994, were prospectively evaluated.

    Associated risk factors, treatment, and outcome were recorded.

    Results 

    Pseudomonas aeruginosa bacteremia represented 5.7% of the total number of bacteremias, 6.9% of nosocomial bacteremias, and 23.6% of nosocomial gram-negative bacteremias.

    There were 1.5 episodes per 1000 discharges.

    These numbers were slightly lower than those recorded at our hospital 10 years earlier.

    Human immunodeficiency virus infection was the most frequent underlying disease (28/189 [15% ]). Overall mortality was 18% (34/189).

    The presence of fatal underlying disease (P<. 001), surgery (P=001), pneumonia (P=02), and severe sepsis (P<. 001) were associated with poor prognosis, the mortality of the patients with these variables being 28%, 28%, 47%, and 62%, respectively.

    The presence of inappropriate definitive antimicrobial treatment became an independent factor predictive of death (P=04) only when the subset of patients with intravenous catheter-associated bacteremia was excluded from the analysis. (...)

    Mots-clés Pascal : Pseudomonas aeruginosa, Pseudomonadaceae, Pseudomonadales, Bactérie, Bactériémie, Bactériose, Infection, Epidémiologie, Incidence, Pronostic, Mortalité, Homme, Espagne, Europe, Milieu hospitalier

    Mots-clés Pascal anglais : Pseudomonas aeruginosa, Pseudomonadaceae, Pseudomonadales, Bacteria, Bacteremia, Bacteriosis, Infection, Epidemiology, Incidence, Prognosis, Mortality, Human, Spain, Europe, Hospital environment

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0483357

    Code Inist : 002B05B02M. Création : 10/04/1997.