Chronic lymphocytic leukaemias and non-Hodgkin's lymphomas by histological type in farming-animal breeding workers : a population case-control study based on a priori exposure matrices.
A population based case-control study was conducted in a highly agricultural area in Italy to investigate the association between chronic lymphocytic leukaemias (CLLs) and non-Hodgkin's lymphomas (NHLs), and subtypes, and exposure to pesticides in farming-animal breeding workers.
Methods-187 cases of CLLs and NHLs and 977 population controls were interviewed on medical, residential, family, and occupational history.
Detailed information was collected about cultivated crops and animals bred from subjects who worked in farming and animal breeding.
Information on crop diseases and pesticides used (and their quantity and duration) was also obtained.
A priori job-exposure matrices were applied when a crop disease was reported, estimating the most probable pesticide and, when possible, an estimate of the cumulative dose.
Odds ratios (ORs) were calculated by unconditional logistic analysis with adjustment for relevant confounders in farmers who bred animals and in farmers alone, for the main crops, types of animals, and pesticides categories.
First recall and then the matrices were used for defining exposure, as it affected CLLs and NHLs and then separately on CLLs and low grade NHLs.
Finally, the dose-response was investigated for those pesticides which had shown some association.
No variable under study was associated with work in farming alone. (...)
Mots-clés Pascal : Leucémie lymphoïde, Lymphome non hodgkinien, Type histologique, Homme, Epidémiologie, Exposition professionnelle, Médecine travail, Agriculteur, Italie, Europe, Pesticide, Chronique, Hémopathie maligne, Lymphoprolifératif syndrome, Elevage, Etude cas témoin
Mots-clés Pascal anglais : Chronic lymphocytic leukemia, Non Hodgkin lymphoma, Histological type, Human, Epidemiology, Occupational exposure, Occupational medicine, Farmer, Italy, Europe, Pesticides, Chronic, Malignant hemopathy, Lymphoproliferative syndrome, Rearing, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0479717
Code Inist : 002B19B. Création : 10/04/1997.