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  1. Effectiveness of influenza vaccine in the elderly.

    Article - En anglais


    Each year, influenza and its complications account for 10,000-40,000 excess deaths in the United States.

    Over 80% of these deaths occur among the elderly.

    The Advisory Committee on Immunization Practices for the US Public Health Service and others recommend that all persons 65 years of age and older as well as other persons with high-risk conditions receive annual influenza vaccination.

    Despite these recommendations, 40% or more of high-risk persons fail to receive influenza vaccine.

    Among the barriers to successful immunization efforts are persistent uncertainties regarding the effectiveness of the vaccine in preventing morbidity and mortality associated with influenza.

    The purpose of this study was to assess influenza vaccine effectiveness in reducing hospitalization rates for a broad range of influenza-associated complications, in reducing deaths from all causes, and in reducing hospitalization costs among all elderly enrollees of a large health maintenance organization.


    A serial cohort study with internal controls was designed.

    All enrollees, 65 years of age and older, were identified for each of three consecutive vaccination and subsequent influenza seasons for 1990-1991 through 1992-1993.

    Baseline characteristics and outcome data were collected from computerized, linked, administrative data bases. (...)

    Mots-clés Pascal : Epidémiologie, Vaccination, Influenzavirus, Orthomyxoviridae, Virus, Efficacité, Complication, Hospitalisation, Grippe, Virose, Infection, Prévention, Article synthèse, Vieillard, Homme

    Mots-clés Pascal anglais : Epidemiology, Vaccination, Influenzavirus, Orthomyxoviridae, Virus, Efficiency, Complication, Hospitalization, Influenza, Viral disease, Infection, Prevention, Review, Elderly, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0479333

    Code Inist : 002B05A02. Création : 10/04/1997.