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  1. Assessment of exposure to polycyclic aromatic hydrocarbons in engine rooms by measurement of urinary 1-hydroxypyrene.

    Article - En anglais

    Objective

    Machinists have an increased risk of lung cancer and bladder cancer, and this may be caused by exposure to carcinogenic compounds such as asbestos and polycyclic aromatic hydrocarbons (PAHs) in the engine room.

    The aim of this study was to investigate the exposure of engine room personnel to PAHs, with 1-hydroxypyrene in urine as a biomarker.

    Methods-Urine samples from engine room personnel (n=51) on 10 ships arriving in different harbours were collected, as well as urine samples from a similar number of unexposed controls (n=47) on the same ships.

    Urinary 1-hydroxypyrene was quantitatively measured by high performance liquid chromatography.

    The exposure to PAHs was estimated by a questionnaire answered by the engine room personnel.

    On two ships, air monitoring of PAHs in the engine room was performed at sea.

    Both personal monitoring and area monitoring were performed.

    The compounds were analysed by gas chromatography of two types (with a flame ionisation detector and with a mass spectrometer).

    Results

    Significantly more 1-hydroxypyrene was found in urine of personnel who had been working in the engine room for the past 24 hours, than in that of the unexposed seamen.

    The highest concentrations of 1-hydroxypyrene were found among engine room personnel who had experienced oil contamination of the skin during their work in the engine room. (...)

    Mots-clés Pascal : Composé aromatique polycyclique, Exposition professionnelle, Médecine travail, Navire, Amiante, Carcinogène, Pétrole, Voie externe, Surveillance biologique, Marqueur biologique, Urine, Salle machine

    Mots-clés Pascal anglais : Polycyclic aromatic compound, Occupational exposure, Occupational medicine, Ship, Asbestos, Carcinogen, Petroleum, Topical administration, Biological monitoring, Biological marker, Urine

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0478922

    Code Inist : 002B03L06. Création : 10/04/1997.