Background-The occurrence of gall stones has repeatedly been associated with an increased risk for cancer of the colon, but risk associated with cholecystectomy remains unclear.
Aims-To evaluate the hypothesis in a nationwide cohort of more than 40 000 gall stone patients with complete follow up including information of cholecystectomy and obesity.
Patients-In the population based study described here, 42098 patients with gall stones in 1977-1989 were identified in the Danish Hospital Discharge Register.
Methods-These patients were linked to the Danish Cancer Registry to assess their risks for colorectal and other cancers during follow up to the end of 1992.
The analysis showed a modest increase in the number of cancers at all sites combined In=3940 ; RR, 1.07 ; 95% confidence intervals (CI), 1.0 to 1.1).
A weak association was found for cancer of the colon In=360 ; RR, 1.09 ; 95% CI 1.0 to 1.2), which remained unchanged when analysed by sex, anatomical subsite, and duration of follow up.
Multivariate analysis with adjustment for cholecystectomy and clinically defined obesity did not change these estimates to any significant extent.
Excess risks were found for cancers of the pancreas and the small intestine.
A non-significant increased risk for breast cancer was seen in women five years after initial discharge for gall stones. (...)
Mots-clés Pascal : Lithiase, Vésicule biliaire, Association morbide, Carcinome, Côlon, Rectum, Intestin, Glande mammaire, Incidence, Epidémiologie, Etude cohorte, Homme, Danemark, Europe, Voie biliaire pathologie, Appareil digestif pathologie, Tumeur maligne, Intestin pathologie, Côlon pathologie, Rectum pathologie, Glande mammaire pathologie
Mots-clés Pascal anglais : Lithiasis, Gallbladder, Concomitant disease, Carcinoma, Colon, Rectum, Gut, Mammary gland, Incidence, Epidemiology, Cohort study, Human, Denmark, Europe, Biliary tract disease, Digestive diseases, Malignant tumor, Intestinal disease, Colonic disease, Rectal disease, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0478439
Code Inist : 002B13B01. Création : 10/04/1997.