Objectives The purpose of this study was to investigate the serial nerve conduction parameters of a group of lead-exposed workers and determine their correlation with the serial blood lead results over a three-year period.
A « nonresponse » level (defined as no significant changes in the nerve conduction in response to changes in the blood lead level of each exposed worker observed over the period of study) was also determined for blood lead in respect to the peripheral nerves.
Methods Seventy-two male workers from a lead battery manufacturing factory were followed at six-month intervals for three years.
At each follow-up, the blood lead level was determined and nerve conduction tests (ulnar and median nerves) were conducted.
A group of 82 unexposed subjects served as referents.
Results Significant differences were observed for some of the mean values of the median nerve conduction parameters between the exposed and reference groups.
The 28 exposed workers who completed the follow-up were divided into the following two blood lead categories :<40 mug. 100 ml-1 (<1.93 mumol. l-1) and = 40 mug. 100 ml-1 (= 1.93 mumol. l-1).
In the latter, the median motor conduction velocity, median distal latency, median amplitude, ulnar motor conduction velocity, and ulnar amplitude were significantly correlated (adjusted for age and within-subject variation) with the blood lead levels, but not so in the former. (...)
Mots-clés Pascal : Plomb, Métal lourd, Exposition professionnelle, Toxicité, Trouble conduction, Conduction nerveuse, Homme, Etude longitudinale, Relation concentration activité, Sang, Taux, Batterie, Industrie, Système nerveux pathologie, Nerf périphérique pathologie, Médecine travail
Mots-clés Pascal anglais : Lead, Heavy metal, Occupational exposure, Toxicity, Conduction disorder, Nerve conduction, Human, Follow up study, Activity concentration relation, Blood, Rate, Battery, Industry, Nervous system diseases, Peripheral nerve disease, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0477834
Code Inist : 002B03L05. Création : 10/04/1997.