Occupational history and genetic N-acetyltransferase polymorphism in urothelial cancer patients of Leverkusen, Germany.
Objectives The study was designed to realize possible shifts in the ratio of slow to fast acetylators within a group of 196 urothelial cancer patients in an area with earlier benzidine production.
Methods The subjects were interviewed for occupational and nonoccupational risk factors.
The patients were phenotyped for N-acetyltransferase 2 (NAT2) by Grant's caffeine test.
A subgroup of 54 patients was additionally genotyped for NAT2.
Results The antimode in the NAT2 phenotyping with the caffeine test (AFMU : 1X ratio) was 1.0, as evidenced by additional genotyping of the subgroup of 54 patients.
The prevalence of slow acetylators in the entire group of bladder cancer patients was 55%, in accordance with published figures for European populations.
In a subgroup of 40 patients with occupational histories as workers in chemical or rubber industries 65% were slow acetylators.
In a further subgroup of 28 cases having specifically worked at chemical production sites of the local chemical industry, 68% were slow acetylators.
Conclusions In contrast to earlier studies, this study shows no increased prevalence of slow acetylators among urothelial cancer patients in comparison with the normal population.
However, in subgroups of cases with a likelihood of past occupational contacts with aromatic amines, there was a trend towards a higher representation of slow acetylators. (...)
Mots-clés Pascal : Tumeur maligne, Vessie urinaire, Homme, Exposition professionnelle, Amine, Composé aromatique, Phénotype acétylateur, Génotype, Arylamine N-acetyltransferase, Acyltransferases, Transferases, Enzyme, Industrie chimique, Industrie caoutchouc, Toxicité, Epidémiologie, Allemagne, Europe, Médecine travail, Appareil urinaire pathologie, Voie urinaire pathologie, Vessie pathologie
Mots-clés Pascal anglais : Malignant tumor, Urinary bladder, Human, Occupational exposure, Amine, Aromatic compound, Acetylator phenotype, Genotype, Arylamine N-acetyltransferase, Acyltransferases, Transferases, Enzyme, Chemical industry, Rubber industry, Toxicity, Epidemiology, Germany, Europe, Occupational medicine, Urinary system disease, Urinary tract disease, Bladder disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0477833
Code Inist : 002B14D02. Création : 10/04/1997.