Hemorheology in occupational lead exposure.
Objectives The purpose of this investigation was to study hemorheological parameters in occupationally lead exposed men.
Material and methods For 15 clinically healthy lead-exposed male subjects [age 34.6 (SD 8) years] the viscous (epsilon') and elastic (epsilon ) components of whole blood viscosity corrected for 45% hematocrit were measured for shear rates between l. s-1 - 100 s-1 at 37°C. Moreover, lead concentrations in blood and urine and the delta-aminolevulinic acid dehydrase level were determined.
Fifteen unexposed age-matched men were used as referents.
Results The mean lead concentration in the blood and urine of the lead-exposed men was 48.7 (SD 16.2) mug. dl-and 38.8 (SD 17.1) mug. g creatinine-1, respectively.
While epsilon was significantly increased only at low shear rates, epsilon'was elevated throughout the investigated shear range in comparison with the values of the unexposed referents.
These results are characteristic of erythrocytes with enhanced rigidity.
The aggregation and filtration index of erythrocytes were significantly elevated for the lead-exposed workers.
A positive correlation existed between lead in blood and epsilon'or epsilon « , whereas delta-aminolevulinic acid dehydrase and epsilon'or epsilon » were inversely correlated.
No differences in plasma viscosity or in lipid status could be detected. (...)
Mots-clés Pascal : Plomb, Métal lourd, Toxicité, Exposition professionnelle, Homme, Sang, Propriété rhéologique, Viscosité, Surveillance biologique, Urine, Erythrocyte, Marqueur biologique, Médecine travail
Mots-clés Pascal anglais : Lead, Heavy metal, Toxicity, Occupational exposure, Human, Blood, Rheological properties, Viscosity, Biological monitoring, Urine, Red blood cell, Biological marker, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0477202
Code Inist : 002B03L05. Création : 10/04/1997.