To evaluate HIV-1 incidence among adults and socio-demographic risk factors in a rural population in Uganda, a prospective cohort study was carried out.
All consenting adult residents in a cluster of 15 neighbouring villages of the Masaka District of south-west Uganda have been participating in annual socio-demographic and serological surveys since November 1989.
Those who had a negative serostatus when they were first tested and had at least one serostatus assessment during the 4 years of follow-up (1990-1994) have been evaluated for HIV-1 seroconversion.
Incidence rates have been calculated per 1000 person-years of observation and socio-demographic characteristics assessed for association with recent seroconversion.
At the baseline survey, of 4175 adults with assessable serostatus (79% of all censused adults), 342 (8.2%) were seropositive.
During 12 588.2 person-years of follow-up 89 seroconversions were identified corresponding to an incidence rate of 7.1 (95% CI : 5.6-8.5).
Overall rates were highest in females aged 20-24 years (15.2) and in males aged 20-44 years (11.6).
There was a significant interaction between age and sex ; the ratio of the rate in females to that in males decreased from 3.3 : 1 to 0.5 : 1 with increasing age.
Rates for males aged =20 years were four times higher than those for younger males. (...)
Mots-clés Pascal : SIDA, Virose, Infection, Virus HIV1, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Epidémiologie, Incidence, Tendance, Milieu rural, Adulte, Homme, Ouganda, Afrique, Facteur risque, Démographie, Statut socioéconomique, Age, Sexe, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, HIV-1 virus, Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, Epidemiology, Incidence, Trend, Rural environment, Adult, Human, Uganda, Africa, Risk factor, Demography, Socioeconomic status, Age, Sex, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0476286
Code Inist : 002B06D01. Création : 10/04/1997.