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  1. Health effects of human T-lymphotropic virus type I (HTLV-I) in a Jamaican cohort.

    Article - En anglais

    Background

    Other than adult T-cell leukaemia (ATL) and HTLV-I associated myelopathy (HAM), the health effects of infection with human T-lymphotropic virus type I (HTLV-I) are not well defined.

    Method

    A cohort of 201 confirmed HTLV-I seropositive Jamaican food service workers and 225 seronegative controls of similar age and sex from the same population was examined.

    A health questionnaire, physical examination, and laboratory tests were performed at enrolment into the cohort in 1987-1988.

    Results

    One of 201 HTLV-I seropositives, but no controls were diagnosed with HAM, for a prevalence of 0.5% (95% confidence interval) (CI) 0.01-2.7%) ; no cases of ATL were diagnosed.

    While there was no difference in current symptoms, the HTLV-I seropositive group was more likely to report a past medical history of hepatitis or jaundice (OR=3.49,95% CI : 0.93-13.08), malaria (OR=2.13,95% CI : 0.96-4.73), and dengue fever (OR=1.37,95% CI : 0.82-2.29) ; however, these differences were of borderline statistical significance.

    Low income HTLV-I seropositive women had lower body weight (P<0.01) and body mass index (P<0.009) than their seronegative counterparts ; similar differences were seen in the smaller male group.

    A trend toward higher prevalence of severe anaemia (haemoglobin<10 g/dl) (12.6% versus 7.7%, P<0.105) and a significantly lower prevalence of eosinophilia (1.0% versus 6.3%, P<0.004) was seen among HTLV-I seropositives compared to controls.

    Conclusions

    (...)

    Mots-clés Pascal : Virose, Infection, Virus HTLV1, Retroviridae, Virus, Epidémiologie, Leucémie cellule T adulte, Myélopathie, Homme, Complication, Hémopathie, Indice masse corporelle, Jamaïque, Antilles, Amérique Centrale, Amérique, Hémopathie maligne, Lymphoprolifératif syndrome

    Mots-clés Pascal anglais : Viral disease, Infection, HTLV-I virus, Retroviridae, Virus, Epidemiology, Adult T cell leukemia, Myelopathy, Human, Complication, Hemopathy, Body mass index, Jamaica, West Indies, Central America, America, Malignant hemopathy, Lymphoproliferative syndrome

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0476262

    Code Inist : 002B05C02J. Création : 10/04/1997.