Workshop on New Approaches, Endpoints and Paradigms for RDAs of Mineral Elements. Grand Forks, ND USA, 1995/09/10.
Information is presented regarding the approaches that have been used to establish dietary recommendations for selenium and iodine.
In the case of selenium, activity of the selenoenzyme glutathione peroxidase has served as a convenient biochemical endpoint forjudging nutritional status.
However, there are differences of opinion among various nutritionists as to whether full expression of this enzymatic activity is required for adequate nutriture, thereby resulting in differences in dietary recommendations.
Endpoints for assessing selenium overexposure are much less satisfactory, but toxicological standards for selenium have nevertheless been established.
Thus far, no nutritionists have attempted to shift the paradigm for determining dietary selenium recommendations away from prevention of deficiency disease to prevention of chronic degenerative disease (e.g., cancer).
In the case of iodine, urinary excretion of the element is the most widely used endpoint forjudging nutritional status.
Numerous epidemiological surveys have been conducted to determine the level of urinary iodine excretion that is consistent with prevention of goiter, the most common endpoint of iodine deficiency.
Because dietary iodine is essentially quantitatively excreted in the urine, determination of the latter in goitrous areas will allow an almost direct estimation of those intakes at risk of developing deficiency disease. (...)
Mots-clés Pascal : Congrès, Article synthèse, Recommandation alimentaire, Sélénium, Iode, Nutrition, Alimentation, Micronutriment, Elément minéral, Oligoélément, Antioxydant, Homme
Mots-clés Pascal anglais : Congress, Review, Dietary allowance, Selenium, Iodine, Nutrition, Feeding, Micronutrient, Inorganic element, Trace element (nutrient), Antioxidant, Human
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0474527
Code Inist : 002B30A02A. Création : 10/04/1997.