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  1. The descriptive epidemiology of anophthalmia and microphthalmia.

    Article - En anglais

    Background

    Anophthalmia and microphthalmia are serious eye malformations which recently have been associated with exposure to Benomyl.

    Data on these malformations are scarce in the literature and reported prevalences at birth vary strongly.

    Methods

    Data from three large registers of congenital malformations were analysed and comprised 849 malformed infants based on close to 5.7 million births.

    Results

    This is the largest available epidemiological study on anophthalmia and microphthalmia.

    The prevalence at birth was 1.50 per 10 000, varying between 0.92 and 2.29 between registers but not varying significantly between races in the California register.

    The variation in rates was mainly due to different inclusion of chromosomally abnormal infants (mainly trisomy 13) and of infants with microphthalmia occurring with major non-eye malformations.

    On the other hand, rates of anophthalmia and isolated microphthalmia were similar.

    Other major non-eye malformations were found in 73% of infants without a known chromosome anomaly.

    The malformation was bilateral in 53-60% of infants except when microphthalmia existed without any other malformations when only 27% were bilateral.

    Sex distribution was normal, there was a slight excess of twins, and an increased risk at high maternal age.

    Conclusions

    (...)

    Mots-clés Pascal : Anophtalmie, Microphtalmie, Epidémiologie, Tératogène, Toxicité, Nourrisson, Homme, France, Europe, Suède, Californie, Etats Unis, Amérique du Nord, Amérique, Registre, Composé chimique, Carbamate, Oeil pathologie, Maladie congénitale, Malformation, Benomyl, Fongicide, Pesticide

    Mots-clés Pascal anglais : Anophthalmos, Microphthalmia, Epidemiology, Teratogen, Toxicity, Infant, Human, France, Europe, Sweden, California, United States, North America, America, Register, Chemical compound, Carbamate, Eye disease, Congenital disease, Malformation, Benomyl, Fungicide, Pesticides

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0473948

    Code Inist : 002A30E. Création : 10/04/1997.