Chronic low-dose exposure to solvents has been associated in epidemiologic studies with chronic neurotoxicity, but the evidence is not consistent.
Styrene causes acute disturbances in the central and peripheral nervous systems.
To determine if exposure to styrene may contribute to chronic diseases of the central nervous system, the authors examined mortality from nervous system diseases, mental disorders, and suicide in relation to styrene exposure in an international historical cohort study.
The cohort involved 35,443 workers employed during 1945-1991 in the reinforced plastics industry, where high exposures to styrene occur.
Indicators of exposure were reconstructed through job histories and environmental and biologic monitoring data.
Poisson regression was used for internal comparisons.
Mortality from diseases of the central nervous system (27 deaths) increased with time since first exposure, duration of exposure, average level of exposure, and cumulative exposure to styrene.
A quadratic model described best the dose-response shape for cumulative exposure and duration of exposure with the highest risks at around 300 ppm-years and 5 years, respectively, and a subsequent decrease in risk in the highest exposure categories.
Mortality from epilepsy increased monotonically with all styrene exposure indicators, while associations for degenerative diseases of the central nervous system were generally weaker. (...)
Mots-clés Pascal : Styrène, Exposition professionnelle, Système nerveux central pathologie, Trouble psychiatrique, Suicide, Industrie matière plastique, Médecine travail, Toxicité, Mortalité, Epidémiologie, Homme, Etude cohorte, Europe, Etude multicentrique, Solvant, Système nerveux pathologie, Santé mentale
Mots-clés Pascal anglais : Styrene, Occupational exposure, Central nervous system disease, Mental disorder, Suicide, Plastics industry, Occupational medicine, Toxicity, Mortality, Epidemiology, Human, Cohort study, Europe, Multicenter study, Solvent, Nervous system diseases, Mental health
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0471823
Code Inist : 002B03L04. Création : 10/04/1997.