A total of 154 cases of thyroid cancer in children under 15 were registered in England and Wales over a period of 30 years, an incidence of about 0.5 per million per year.
A total of 4.5 cases per year were registered in 1963-72,4.9 in 1973-82 and 5.8 in 1983-92.
A rapid rise in incidence with age occurred after the age of 5. Malignancy was confirmed in 92% of the cases in which tissue was available.
Of these, 68% were papillary carcinomas, 11% follicular carcinomas and 17% medullary carcinomas.
There were two spindle cell tumours with mucous cysts and one teratoma.
The increased frequency but small size of medullary carcinomas in the second half of the period suggested that this increase was due to the introduction of screening ; it accounted for most of the rise in crude incidence rates with time.
The sex ratio (F : M) in all registered cases in the differentiated follicular cell carcinoma groups in children aged under 10 was 1.2 : 1, and 3.6 : 1 in the older children.
Five children with differentiated thyroid cancer of follicular cell origin died up to 17 years after diagnosis.
Two of the eight children aged 9 or less with a 20 year follow-up died, compared with three of 28 older children.
An unusual group of differentiated carcinomas showed solid or follicular architecture.
These tumours were unencapsulated, often widely invasive, contained psammoma bodies but little or no papillary architecture and the nuclei often lacked prominent grooving. (...)
Mots-clés Pascal : Tumeur maligne, Thyroïde, Incidence, Epidémiologie, Type histologique, Angleterre, Grande Bretagne, Royaume Uni, Europe, Pays de Galles, Enfant, Homme, Thyroïde pathologie, Endocrinopathie
Mots-clés Pascal anglais : Malignant tumor, Thyroid gland, Incidence, Epidemiology, Histological type, England, Great Britain, United Kingdom, Europe, Wales, Child, Human, Thyroid diseases, Endocrinopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0471560
Code Inist : 002B21C02. Création : 10/04/1997.