In a previous study in France, we reported that the relative risk of breast cancer associated with a family history of breast cancer was higher in those subjects with a history of abortions.
The present study was undertaken to check the existence of this interaction in other studies and to investigate whether the interaction is modified by the time at which abortions occur.
Data were obtained from six case-control studies in France, Australia and Russia, with information on family history of breast cancer and abortion for 2693 breast cancer cases and 3493 controls.
The interaction effect was estimated in each study separately, then combined using a multivariate weighted average.
The relative risk conferred by a family history of breast cancer increased with the number of abortions (1.8 for no abortion, 1.9 for one abortion, 2.8 for two or more).
There was a significant interaction between total number of abortions and family history (P=0.04), but this was no longer significant when adjusted for other risk factors.
The familial risk was highest for those who had had an abortion before first childbirth (1.9 for abortion after first childbirth, 2.7 for abortion before first childbirth).
The adjusted risk associated with family history was significantly higher in those with an abortion before first childbirth (P=0.04).
Our findings suggest a synergism between familial factors and abortion. (...)
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Facteur risque, Avortement, Antécédent, Etude familiale, Epidémiologie, France, Europe, Australie, Océanie, Russie, Eurasie, Avortement provoqué, Homme, Glande mammaire pathologie, Gestation pathologie, Etude cas témoin
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Risk factor, Abortion, Antecedent, Family study, Epidemiology, France, Europe, Australia, Oceania, Russia, Eurasia, Induced abortion, Human, Mammary gland diseases, Pregnancy disorders, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0471552
Code Inist : 002B20E02. Création : 10/04/1997.