Several studies have demonstrated differences between ethnic groups in the severity and pattern of rheumatoid arthritis (RA) and osteoarthritis (OA).
The current investigation compared RA and OA in Pakistani and British White Caucasian out-patients in two teaching hospitals.
There were 88 RA patients in each setting, matched for age, gender and disease duration.
The pattern of OA was sought by recording the details of 44 consecutive new referrals to each clinic.
Amongst the RA patients, joint deformity and tenderness were similar, but disability was more severe, ESR higher, anaemia more pronounced and RA latex more often positive amongst the Pakistani patients.
X-ray damage was more pronounced amongst the British patients, especially in the feet.
The British were also more likely to have rheumatoid nodules and to have undergone disease-modifying treatment or joint surgery.
The paradox of more severe indices of disease activity and disability with less X-ray erosion in hands and feet might be explained by the impact of treatment on joint inflammation and the beneficial influence of surgery on disability in the British.
The worse X-ray scores in the White Caucasians might indicate a genetic predisposition to radiologically more severe disease.
The age of the British OA patients was significantly higher, but this is unlikely to have influenced the striking disparity in the frequency of isolated knee OA, which was significantly greater in the Pakistani patients. (...)
Mots-clés Pascal : Polyarthrite rhumatoïde, Homme, Arthrose, Etude comparative, Ethnie, Caucasoïde, Angleterre, Grande Bretagne, Royaume Uni, Europe, Pakistan, Asie, Symptomatologie, Epidémiologie, Forme clinique, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Immunopathologie, Maladie autoimmune, Arthropathie, Maladie dégénérative
Mots-clés Pascal anglais : Rheumatoid arthritis, Human, Osteoarthritis, Comparative study, Ethnic group, Caucasoid, England, Great Britain, United Kingdom, Europe, Pakistan, Asia, Symptomatology, Epidemiology, Clinical form, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Immunopathology, Autoimmune disease, Arthropathy, Degenerative disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0470099
Code Inist : 002B15D. Création : 10/04/1997.