Geographic variations in the histopathologic pattern of non-Hodgkin's lymphoma (NHL) are well documented.
Insight into this epidemiologic data might shed light on the underlying etiology.
Currently, there is a paucity of information regarding the pattern of NHL occurring in Thailand and Southeast Asia.
The current nationwide study was undertaken to obtain a clearer definition of the disease among Thais and to compare this information with data from other Asian and Western countries.
A retrospective analysis of histopathologic subtypes and clinical features was conducted in 1391 patients (age = 15 years) with NHL who were treated at 6 major medical centers in 4 representative areas of Thailand.
One hundred and thirty unselected cases were immunohistochemically studied.
The reports from other countries used for comparison were identified through a computerized search on MEDLINE.
Of the total cases studied, follicular lymphomas constituted 3.8% and diffuse lymphomas 91.4%. The frequency of low and intermediate grade (including large cell immunoblastic, using the Working Formulation) were 12.8% and 72.9%, respectively.
The most common histologic subtype was the diffuse large cell and large cell immunoblastic entity, which constituted 39.9% of the cases studied.
The rate of small lymphocytic and diffuse small cleaved subtypes were higher than in the United States.
Of the 130 cases studied, T-cell lymphoma comprised 16. (...)
Mots-clés Pascal : Lymphome non hodgkinien, Homme, Epidémiologie, Incidence, Thaïlande, Asie, Forme clinique, Type histologique, Phénotype, Lymphocyte B, Lymphocyte T, Hémopathie maligne, Lymphoprolifératif syndrome, Anatomopathologie
Mots-clés Pascal anglais : Non Hodgkin lymphoma, Human, Epidemiology, Incidence, Thailand, Asia, Clinical form, Histological type, Phenotype, B-Lymphocyte, T-Lymphocyte, Malignant hemopathy, Lymphoproliferative syndrome, Pathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0470029
Code Inist : 002B19B. Création : 10/04/1997.