It has been suggested that juvenile chronic arthritis (JCA) is associated with coeliac disease in a frequency of 0.4-2%. In order to investigate the frequency of coeliac disease in cases of JCA and the possibility of underdiagnosis in our area, we screened 62 children with JCA (mean age 9.8 ± 3.5 year) for coeliac disease.
All children were screened for coeliac disease by measuring the IgA-class of antigliadin, antireticulin and antiendomysium antibodies in serum and by measuring intestinal permeability by a sugar absorption test using lactulose and mannitol.
In cases of at least one positive test, a small-bowel biopsy for diagnosis of coeliac disease was offered.
Of the 62 children with JCA, 8 had an abnormal screening result and were suspected of having coeliac disease.
In four of the five children in whom a small-bowel biopsy, was performed, the intestinal mucosa was normal and in one child villous atrophy characteristic of coeliac disease was found.
Therefore, the prevalence of coeliac disease in our study group was 1.5%, which is in agreement with the literature.
These findings indicate no underdiagnosis of coeliac disease in JCA in our area.
Mots-clés Pascal : Arthrite chronique juvénile, Enfant, Homme, Association, Coeliaque maladie, Prévalence, Pays Bas, Europe, Dépistage, Epidémiologie, Chronique, Rhumatisme inflammatoire, Système ostéoarticulaire pathologie, Appareil digestif pathologie, Intestin pathologie, Malabsorption intestinale, Immunopathologie
Mots-clés Pascal anglais : Juvenile rheumatoid arthritis, Child, Human, Association, Coeliac disease, Prevalence, Netherlands, Europe, Medical screening, Epidemiology, Chronic, Inflammatory joint disease, Diseases of the osteoarticular system, Digestive diseases, Intestinal disease, Intestinal malabsorption, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0469821
Code Inist : 002B15D. Création : 10/04/1997.