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  1. Age-related differences in patients with nonpalpable breast carcinomas.

    Article - En anglais

    BACKGROUND

    The survival benefit of screening mammography may be influenced by the age of the screened population.

    The current series examines the influence of age on the clinical, histopathologic, and prognostic features of nonpalpable breast carcinoma.

    METHODS

    Needle localization and biopsy of suspicious mammographic lesions identified 173 breast carcinomas that were occult by physical examination.

    The mammographic appearance, the tumor histology and size, as well as axillary lymph node and estrogen receptor status of these carcinomas were reviewed.

    RESULTS

    Mammographic findings of a mass or density (without calcifications) were most common (46%) and the majority of tumors were invasive ductal carcinoma (70%). The median age of the patients was 59 years.

    Tumor histology and mammographic findings varied by age : women with ductal carcinoma in situ (DCIS) had a median age of 50 years, whereas patients with invasive ductal carcinoma without associated intraductal tumor had a median age of 65 years.

    Both younger age (P=0.001) and microcalcifications (P=0.0001) were strongly correlated with DCIS.

    The mean greatest tumor dimension was 1.34 cm.

    Axillary metastases were found in 21%, 15%, and 50% of invasive tumors with sizes of<1 cm,<2 cm, and>2 cm, respectively, and were uninfluenced by age.

    Estrogen receptor analysis of invasive tumors was>10 fmol/mg in 47% and 84% of women aged<50 years and>50 years, respectively.

    CONCLUSIONS

    (...)

    Mots-clés Pascal : Carcinome, Glande mammaire, Femelle, Homme, Asymptomatique, Dépistage, Pronostic, Age, Mammographie, Histologie, Prévention, Tumeur maligne, Glande mammaire pathologie, Radiodiagnostic, Exploration radiologique, Anatomopathologie

    Mots-clés Pascal anglais : Carcinoma, Mammary gland, Female, Human, Asymptomatic, Medical screening, Prognosis, Age, Mammography, Histology, Prevention, Malignant tumor, Mammary gland diseases, Radiodiagnosis, Radiologic investigation, Pathology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0469718

    Code Inist : 002B20E02. Création : 10/04/1997.