This study investigates whether a positive family history of breast carcinoma is associated with improved survival after invasive breast carcinoma among women ages 21 through 45.
Subjects were 733 nonadopted women born after 1944 who were diagnosed with primary invasive breast carcinoma between January 1983 and April 1990 while residing in the metropolitan Seattle area and who provided information on family history of breast carcinoma.
Information on clinical characteristics and survival was obtained from a population-based cancer registry.
Cox proportional hazards models were used to estimate the relative risk (RR) of dying in relation to family history of breast carcinoma, adjusting for selected clinical characteristics, age and year of diagnosis, and prior mammograms.
The risk of dying among women with a first-degree family history of breast carcinoma was half that of women with no family history of breast carcinoma (RR=0.5 ; 95% confidence interval [CI], 0.3-0.9).
There was no evidence of a reduction in the risk of dying among women with only a second-degree family history of breast carcinoma (RR=1 ; 95% Cl, 0.6-1.4).
These associations were adjusted for age and year of diagnosis, stage of disease, tumor size, bilaterality, and mammogram history. (...)
Mots-clés Pascal : Carcinome, Glande mammaire, Femelle, Homme, Antécédent, Histoire familiale, Pronostic, Survie, Epidémiologie, Déterminisme génétique, Facteur risque, Tumeur maligne, Glande mammaire pathologie
Mots-clés Pascal anglais : Carcinoma, Mammary gland, Female, Human, Antecedent, Family story, Prognosis, Survival, Epidemiology, Genetic inheritance, Risk factor, Malignant tumor, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0469716
Code Inist : 002B20E02. Création : 10/04/1997.