It has been suggested that identified risk factors for endometrial cancer operate through a single etiologic pathway, i.e., exposure to relatively high levels of unopposed estrogen (estrogen in the absence of progestins).
Only a few studies, however, have addressed this issue directly.
We assessed the risk of developing endometrial cancer among both premenopausal and postmenopausal women in relation to the circulating levels of steroid hormones and sex hormone-binding globulin (SHBG).
The independent effect of hormones was assessed after adjustment for other known risk factors.
The data used in the analysis are from a case-control study conducted in five geographic regions in the United States.
Incident cases were newly diagnosed during the period from June 1,1987, through May 15,1990.
The case patients, aged 20-74 years, were matched to control subjects by age, race, and geographic region.
The community control subjects were obtained by random-digit-dialing procedures (for subjects 20-64 years old) and from files of the Health Care Financing Administration (for subjects =65 years old).
Additional control subjects who were having a hysterectomy performed for benign conditions were obtained from the participating centers. (...)
Mots-clés Pascal : Tumeur maligne, Endomètre, Préménopause, Androstènedione, Postménopause, SBP, Oestrone, Oestradiol, Globuline, Facteur risque, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Albumine, Homme, Appareil génital femelle pathologie, Utérus pathologie, Hormone stéroïde sexuelle, Androgène, Oestrogène, Hormone ovarienne, Etude cas témoin
Mots-clés Pascal anglais : Malignant tumor, Endometrium, Premenopause, Androstenedione, Postmenopause, Sex hormone binding protein, Estrone, Estradiol, Globulin, Risk factor, Epidemiology, United States, North America, America, Albumin, Human, Female genital diseases, Uterine diseases, Sex steroid hormone, Androgen, Estrogen, Ovarian hormone, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0466749
Code Inist : 002B20C02. Création : 10/04/1997.