Despite mandatory antibody testing, human immunodeficiency virus (HIV) can be transmitted from HIV-infected blood that is seronegative.
The objective of this study was to estimate the probability of HIV-infected blood donations during the seronegative « window period » in a northern Thailand HIV epicenter.
Thus, a retrospective cohort of repeat blood donors was created.
With the assumptions that the probability of HIV seroconversion is distributed uniformly between the last HIV-negative and the first HIV-positive donation and that the seronegative window is 45 days, the rate of window-period donations was calculated by multiplying the incidence by the window duration.
Of 11,232 repeat donors, 273 seroconverted during 9,518,863 person-days of observation (i.e., a window-period donation rate of 1/775).
There were more window-period donations among 21-to 30-year-old men and in donors replacing blood of friends or relatives.
Additional measures are needed to reduce the high number of HIV-infected window-period donations.
Mots-clés Pascal : SIDA, Virose, Infection, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Incidence, Délai, Homme, Sang, Donneur sang, Thaïlande, Asie, Séronégativité, Transmission, Epidémiologie, Iatrogène, Immunopathologie, Immunodéficit, Prévention, Séroconversion
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, Incidence, Time lag, Human, Blood, Blood donor, Thailand, Asia, Seronegativity, Transmission, Epidemiology, Iatrogenic, Immunopathology, Immune deficiency, Prevention
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 96-0465107
Code Inist : 002B06D01. Création : 10/04/1997.