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  1. An estimate of the number of human immunodeficiency virus (HIV) - positive blood donations by HIV-seronegative donors in a Northern Thailand HIV epicenter.

    Article - En anglais

    Despite mandatory antibody testing, human immunodeficiency virus (HIV) can be transmitted from HIV-infected blood that is seronegative.

    The objective of this study was to estimate the probability of HIV-infected blood donations during the seronegative « window period » in a northern Thailand HIV epicenter.

    Thus, a retrospective cohort of repeat blood donors was created.

    With the assumptions that the probability of HIV seroconversion is distributed uniformly between the last HIV-negative and the first HIV-positive donation and that the seronegative window is 45 days, the rate of window-period donations was calculated by multiplying the incidence by the window duration.

    Of 11,232 repeat donors, 273 seroconverted during 9,518,863 person-days of observation (i.e., a window-period donation rate of 1/775).

    There were more window-period donations among 21-to 30-year-old men and in donors replacing blood of friends or relatives.

    Additional measures are needed to reduce the high number of HIV-infected window-period donations.

    Mots-clés Pascal : SIDA, Virose, Infection, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Incidence, Délai, Homme, Sang, Donneur sang, Thaïlande, Asie, Séronégativité, Transmission, Epidémiologie, Iatrogène, Immunopathologie, Immunodéficit, Prévention, Séroconversion

    Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, Incidence, Time lag, Human, Blood, Blood donor, Thailand, Asia, Seronegativity, Transmission, Epidemiology, Iatrogenic, Immunopathology, Immune deficiency, Prevention

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 96-0465107

    Code Inist : 002B06D01. Création : 10/04/1997.